This study assesses the maturation of the serum antibody response of children and Adults to polysaccharide antigens. Serial serum samples from children and various ages will be assayed for antipolysaccharide antibody with respect to IgG subclass distribution and clonal diversity. Throat cultures are obtained to evaluate antigen (pneumococcus, group A beta strep) exposure.

Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost
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