This is an investigator-initiated, multicenter, randomized, crossover design study to compare the therapeutic effectiveness of split-mixed BID insulin using human regular and ultralente insulin or pork regular and NPH. All subjects (20 from each of 5 centers; 100 in total) must have IDDM, be 4-11 years old, and be prepubertal. Each will be treated for six months with each regimen in randomized sequence. Glycemic control and hypoglycemia rates will be assessed.

Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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