This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endurance exercise is important fo a healthy life: it is essential for long term weight management and is involved in the prevention of cardiovascular disease (CVD), presumably via its ability to lower plasma triglyceride (TG) concentrations (both under fasted conditions and after a meal). There is a direct relationship between elevated plasma TG contrations, 1,2, which are commonly observed in obese persons3, and CVD, particularly in women 4,5. According to a recent report by the American Heart Association, >40% of female deaths in the US and most developed countries occur from CVD, one-third is thought to be attributable to inactivity6. The mechanisms that are responsible for the exercise-induced reduction in plasma TG concentrations are not known. In order to optimize therapies for the prevention of CVD, however, it is ultimately necessary to understand the factors that control plasma TG concentrations. Furthermore, most studies that sougth to investigate potential mechanism(s) for the decrease in plasma TG concentration in response to exercise to date have been performed in lean, oftentimes trained, men but not in obese persons and women. We 7-9, and others 10-11, found that both sex and adiposity affect lipik metabolism, which preludes the generalization of findings from lean subjects and men and underlines the importance of studies specifically targeted to women and obese subjects.
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