This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiomyopathy is a frequent complication of diabetes that contributes significantly to increased morbidity and mortality amongst affected individuals. This proposal will test the hypothesis that diabetic cardiomyopathy is directly related to dyslipidemia, which alters lipid homeostasis in non-adipose tissues such as the heart. We seek to correlate sensitive new echocardiographic measures of early diabetic alterations in cardiac structure and function with lipidomic profiling of platelets, proton magnetic resonance spectroscopy of intramyocellular triglyceride in skeletal muscle, retinal lipid deposits, and fasting serum triglycerides and free fatty acids. Our goal is to develop novel biomarkers and practical non-invasive methods for diagnosing the earliest structural and functional abnormalities in diabetic cardiomyopathy and for guiding therapy that may be applied to population-based practice.
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