This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Because brain activity has been associated with food stimuli and brain activity differs in the fasted and fed states, studies are not needed to understand differences in brain activity in obese compared to normal weight persons. The neural response may provide important data to understand mechanisms involved in overeating and obesity. The purpose of the pilot proposal is to determine the feasibility of mapping the brain's response to hunger, satiety and satisfaction in obese persons.This study will use 15O labeled water and Positron Emission Tomography (PET) to measure regional cerebral blood flow in persons in the fasted, fed, and fully satiated states. To our knowledge, this study has not been previously reported so this will serve as feasibility data for designing future studies. The study will also allow for correlations between biochemical measures, (including insulin and fee fatty acids) and brain activity.
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