Alpha-Interferon (IFN) has been approved by the FDA for the treatment of chronic hepatitis C. unfortunately, this treatment has a less than 20% sustqained response rate (i.e., normal alanine aminotransferase for 12 months after therapy is discontinued). patients with chronic hepatitis C have been shown to have elevated hepatic iron levels, and the likelihood of response to IFN has been shown to be inversely proportional to the hepatic iron concentration. The current study is designed to enroll patients with chronic Hepatitis C who have failed to respond to standard IFN therapy alone. Patients will be treated with iron reduction therapy followed by a course of IFN at their most recent dose, provided it is between 3 million units three times a week and 5 million units daily. The duration of IFN therapy will match that of their most recent course of treatment, i.e., from 6-12 months.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000037-39S1
Application #
6113087
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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