Manipulation of the immune system offers a potential modality for the treatment of cancer with high specificity. The primary obstacles have been the difficulty identifying useful target antigens and developing a means of isolating and expanding T cells recognizing these antigens. Tyrosinase has been identified as a potential target antigen for melanoma and our preliminary data demonstrate that it is possible to isolate and expand tyrosinase-specific CD8+ CTL clones from the peripheral blood of patients with melanoma using recombinant vaccinia viruses. However, since these antigens also represent normal self proteins, the use of T cells specific for tyrosinase, in the treatment of metastatic melanoma poses concerns with respect to autoimmune injury. In this study, we investigate the feasibility of isolating antigen-specific tumor-reactive T cells from patients with melanoma nd determine, in a clinical trial, the safety, efficacy and in vivo persistence of infused T cell clones.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000037-39S1
Application #
6263526
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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