The HER-2/neu oncogene is amplified and overexpressed in 20-40% of interductal carcinomas of the breast and 30% of ovarian cancers. Overexpression of the protein in both these malignancies is associated with aggressive disease and is an independent predictor of poor prognosis in several subsets of patients. Some patients with breast cancer have existent T cell and antibody immunity to HER-2/neu. HER-2/neu is a self-protein. Therefore, it had been assumed that patients would be immunologically tolerant and that immunity could not be generated.

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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