This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this proposal is to determine the safety and feasibility of an exercise intervention in survivors (N=10) of sudden cardiac arrest (SCA) who have automatic implantable cardioverter defibrillators (ICDs). Secondarily, testing the impact of exercise on cardiac autonomic function (heart rate variability (HRV), health outcomes (heart rhythm stability, general health related quality of life, psychological distress), and major adverse cardiac events (cardiac hospitalizations, ER visits, and cardiac mortality) is proposed. The primary outcomes are safety and feasibility in implementing the exercise intervention from baseline to 8 weeks. Our interest is in determining if exercise will affect cardiac parasympathetic nervous system regulation and convey cardioprotective effects on recurrence of ventricular arrhythmias, ICD shocks, and cardiac mortality.
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