This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cranberry juice is a widely used 'folk remedy' to prevent and treat urinary tract infections (UTIs) in spite of limited evidence of its efficacy. For prevention of UTIs, the limited amount of conflicting data suggests that cranberry juice has possible efficacy based on the clinical studies reviewed in a recent Cochrane Review. Further information is needed regarding the efficacy of cranberry juice in the treatment of UTIs; its efficacy will need to be evaluated in combination with Amoxicillin, a commonly used treatment. The present proposal focuses on the hypothesis that cranberry juice ingredients or its byproducts arising from systemic metabolism interfere with the intestinal and renal transport of -lactam antibiotics (amoxicillin), which result in a diminished output of the antibiotics in urine with perhaps an attendant change in its efficacy treatment of UTIs.
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