This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Systemic Lupus Erythematosus (SLE) is an uncommon, potentially life-threatening, autoimmune disease of inflammation of the blood vessels all over the body. In children, the most common organs affected are the skin, the joints, the kidney, the heart and the brain. In general, childhood SLE is more severe than it is in adults because more organs are affected and affected more severely. Atherosclerosis is a disease common in older adults and is caused by a narrowing of the blood vessels caused by fatty deposits to the lining of the vessels. Atherosclerosis increases the risk of cardiac infarction and stroke. Lipid-lowering drugs lower the fat content in blood, prevent further fat from sticking to the lining of blood vessels and also may dissolve fatty deposit on blood vessels. These drugs have been shown to reduce the risk of heart attack and stroke. Because of the inflammation in their blood vessels and abnormalities in the way their bodies handle fat, patients with SLE are more likely to develop atherosclerosis at an earlier age. Patients with SLE are at an increase risk for cardiac infarction and stroke. In this study, we plan to assess children and adolescents with SLE for the development of atherosclerosis over a period of three years. Additionally, + of the study subjects will take a lipid-lowering agent and + of the subjects will take a placebo. We hope the show that the children who take the lipid-lowering agent develop less atherosclerosis.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000037-47
Application #
7603532
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2007-09-16
Budget Start
2007-04-01
Budget End
2007-09-16
Support Year
47
Fiscal Year
2007
Total Cost
$2,434
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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