This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This study is a longitudinal single center pilot study designed to describe changes of a non-invasive biomarker of airway inflammation in infants during and after respiratory syncytial virus (RSV) infection. 30 previously healthy full-term infants ages 0-9 months who are admitted to CHRMC for confirmed RSV respiratory infection will be enrolled. An investigator will administer a demographic and medical history questionnaire and perform a focused physical exam including anthropometric measurements to calculate thoracic index. Mixed expiratory eNO and eNO output measurements will be performed during tidal breathing over 60 seconds without sedation. Infants with RSV infection will return to the GCRC pediatric satellite at CHRMC for 2 follow up visits at 6 months and 12 months after hospital discharge. During the follow up visits, an investigator will administer a questionnaire regarding respiratory symptoms. Serum IgE and CBC with differential will be collected at enrollment and final study visit.
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