This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary purpose of this study is to demonstrate that deep brain stimulation (DBS) of the globus pallidus internal or subthalamic nucleus improves the signs of parkinsonian motor abnormalities more effectively than unilateral stimulation, and DBS is more effective than pallidotomy or medication in relieving the parkinsonian motor signs.
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