This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this K12 proposal, investigators hypothesize that B12 levels in subjects with Parkinson's disease are significantly lower than both age-matched controls and cohabiting caregiver controls. In addition, they hypothesize that supplementation of vitamin B12 in patients with low values will improve their memory, affective symptoms, motor functioning, quality of life, and markers for reducing the risk for vascular disease and dementia.
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