This is an application for a five-year renewal of a General Clinical Research Center at the Hospital of the University of Pennsylvania and at the School of Dental Medicine of the University of Pennsylvania. A multidisciplinary collaborative approach to clinical research continues to be a strong emphasis of all GCRC investigators. The GCRC is used by investigators from the Departments of Pediatrics, Medicine, Dermatology, Psychiatry, Neurology, Radiology, Physical Medicine and Rehabilitation, The Monell Center for the Study of Smell and Taste and by a number of individuals in multidisciplinary centers such as the Center for the Interaction of Hormones and Physical Stress on Bone Mass, Center for Research on Treatment and Prevention of Intravenous Drug Abuse, SCOR In Cardiopulmonary Disorders During Sleep, MHCRC-Regional Brain Function in Schizophrenia, Diabetes Research Center, and Functional Brain Imaging Center for the Study of Mental Disorders. There is a tremendous amount of collaboration between individuals in Neurology, Neurosurgery, Radiology, Psychiatry, and Endocrinology in the development of a variety of innovative approaches to imaging the central nervous system in patients with a variety of neuropsychological disorders, an important theme of the Center. The development of a Core Laboratory has provided a strong new resource for investigators from a variety of laboratories to develop techniques which are not readily available and which dramatically enhance their research activities. In addition to the patient care-related facilities, there is a core CDMAS facility which is also utilized by the CRC investigators from the Children's Hospital of Philadelphia and the University of Pennsylvania Dental School. Research protocols deal with a wide spectrum of diseases, mostly of a metabolic nature, which require specialized facilities for patient observation, close nursing care, and dietary control. New initiatives are proposed in Maternal-Neonatal Medicine, Sleep Disorders, and in Molecular Biology.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Khalili, Mandana; Shuhart, Margaret C; Lombardero, Manuel et al. (2018) Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B. Diabetes Care 41:1251-1259
Thomas, Bernadette; Matsushita, Kunihiro; Abate, Kalkidan Hassen et al. (2017) Global Cardiovascular and Renal Outcomes of Reduced GFR. J Am Soc Nephrol 28:2167-2179
Ojiro, Keisuke; Qu, Xiaowang; Cho, Hyosun et al. (2017) Modulation of Hepatitis C Virus-Specific CD8 Effector T-Cell Function with Antiviral Effect in Infectious Hepatitis C Virus Coculture Model. J Virol 91:
Di Bisceglie, A M; Lombardero, M; Teckman, J et al. (2017) Determination of hepatitis B phenotype using biochemical and serological markers. J Viral Hepat 24:320-329
Lok, A S; Ganova-Raeva, L; Cloonan, Y et al. (2017) Prevalence of hepatitis B antiviral drug resistance variants in North American patients with chronic hepatitis B not receiving antiviral treatment. J Viral Hepat 24:1032-1042
Leonard, Mary B; Shults, Justine; Long, Jin et al. (2016) Effect of Low-Magnitude Mechanical Stimuli on Bone Density and Structure in Pediatric Crohn's Disease: A Randomized Placebo-Controlled Trial. J Bone Miner Res 31:1177-88
Ricordi, Camillo; Goldstein, Julia S; Balamurugan, A N et al. (2016) National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 65:3418-3428
Evon, Donna M; Wahed, Abdus S; Johnson, Geoffrey et al. (2016) Fatigue in Patients with Chronic Hepatitis B Living in North America: Results from the Hepatitis B Research Network (HBRN). Dig Dis Sci 61:1186-96
Park, Jang-June; Wong, David K; Wahed, Abdus S et al. (2016) Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B. Gastroenterology 150:684-695.e5
Hering, Bernhard J; Clarke, William R; Bridges, Nancy D et al. (2016) Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia. Diabetes Care 39:1230-40

Showing the most recent 10 out of 423 publications