There are 4 purposes of this study: (1) to compare the efficacy of continuing AZT/ddI vs adding 3TC or switching to AZT/3TC. (2) to determine the influence of virus load, CD4+ cell counts, biologic phenotypes and the presence of symptomatic HIV disease on the response to a new therapeutic regimen. (3) to determine the influence of virus load, CD4+, and biologic phenotypes and the presence of symptomatic HIV disease on the kinetics of viral replication. (4) to determine the influence of virus load, CD4, biologic phenotypes, and the presence of symptomatic HIV disease on the rate of emergence of the 3TC associated resistance mutation at codon 184.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000040-37S4
Application #
2757472
Study Section
Project Start
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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