Abstract

Tourette's Syndrome (TS) is an idiopathic hyperkinetic movement disorder marked by the presence of tics and psychiatric manifestations. Clinical and pathological data implicate alterations of striatal function in the pathophysiology of TS. The inadequacy of existing animal models, however, has resulted in incomplete knowledge of the mechanisms underlying the pathophysiology of tics and better understanding of the pathophysiology of tics is necessary to develop improved symptomatic therapies for tics. Clinical pharmacology and other data suggest that abnormalities of striatal dopaminergic neurotransmission are involved in the pathophysiology of hyperkinetic tics. Positron emission tomography with appropriate ligands offers the opportunity to probe striatal dopaminergic function in TS. We propose to probe striatal dopaminergic function in patients with TS by using [11C]dihydrotetrabenzine (DTBZ) as a measure of striatal dopamine terminal integrity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000042-36
Application #
5217637
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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As-Sanie, Sawsan; Kim, Jieun; Schmidt-Wilcke, Tobias et al. (2016) Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain. J Pain 17:1-13

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