We hypothesize that the vaccination of patients with autologous tumor cells admixed with BCG will induce a T cell immune response within draining lymph nodes from the site of the vaccine. To test this hypothesis, patients with advanced malignancies are vaccinated with irradiated autologus tumor cells admixed with BCG intradermaly and the draining lymph nodes removed one week later for ex vivo activation. After a period of activation, the cells are reinfused into the patients along with the administration of IL-2. To date, in 11 melanoma patients and 12 renal cell cancer patients we have documented the ability to generate highly specific vaccine-primed T lymphocytes reactive to autologous tumor. Significant tumor regression has been noted in some of these patients after adoptive transfer of the cells. We are continuing this study in advanced renal cell cancer patients to correlate in vitro immunological function of T cells with in vivo tumor reactivity.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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