We have recently begun in vivo human studies that are directed at investigating the role of GHRH in GH secretion, using as a tool, a specific antagonist to GHRH, GHRH-Ant. These studies have allowed us to definitively assign an important role to GHRH in the generation of spontaneous GH pulses in humans as well as to determine that the GH responses to L-dopa and arginine are GHRH dependent. We are now extending our preliminary investigations to explore the mechanisms responsible for GH deficiency in the elderly by determining the dose responses of GH to GHRH-Ant.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000042-39S1
Application #
6113488
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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