Abstract

Hepatitis C is one of the most common causes of chronic liver disease world-wide. It has been estimated that globally there are 200 million hepatitis C virus (HCV) infected individuals. In the United States, there are approximately 4 million HCV infected individuals accounting for 8,000-10,000 deaths annually. HCV-related cirrhosis is responsible for 30% of adult liver transplantations in this country. The natural history of chronic hepatitis C virus (HCV) infection varies from spontaneous resloution to slowly progressive liver disease to development of cirrhosis within 20 years of infection. Very little is known about the mechanisms of HCV-induced liver injury and the factors that determine the rate of progression of chronic hepatitis C. Several studies have identified a subset of patients with chronic HCV infection who have persistently normal alanine aminotransferase (ALT) levels. While some of these patients have chronic hepatitis on liver biopsy, the majority have no or non-specific changes only. Careful comparison of these patients with those who have abnormal ALT levels may identify factors that differentiate these two groups of patients thus leading to improvement in our understanding of the pathogenesis of HCV-induced liver disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000042-39S1
Application #
6113548
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

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Kadakia, Kunal C; Kidwell, Kelley M; Seewald, Nicholas J et al. (2017) Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors. Breast Cancer Res Treat 164:411-419
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As-Sanie, Sawsan; Kim, Jieun; Schmidt-Wilcke, Tobias et al. (2016) Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain. J Pain 17:1-13

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