Abstract

IgA nephropathy is a disease of the kidneys which leads to loss of blood and protein in the urine and can lead to severe kidney failure even when it begins in childhood. Unfortunately, there is no proven treatment for IgA nephropathy, although numerous medications have been tried. Vitamin E is a naturally occurring substance that has """"""""anti-oxidant"""""""" effects, meaning that it can protect against damage caused by certain oxygen-containing substances called """"""""free radicals. Based upon studies in rats with experimental IgA Nephropathy, some researchers feel that giving Vitamin E to children with IgA Nephropathy may reduce or prevent the development of kidney scarring and therefore reduce the chances of developing kidney failure. This is a multicenter study in which children and young adults with biopsy-proven, clinically mild IgA Nephropathy will be randomized to receive either Vitamin E or placebo once daily for two years. Subjects in the study will be followed for changes in kidney function, hematuria (blood in the urine), and proteinuria to learn whether Vitamin E is an effective treatment for IgA Nephropathy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000042-40
Application #
6303476
Study Section
Project Start
1999-12-01
Project End
2001-02-28
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
40
Fiscal Year
2000
Total Cost
$206
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

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As-Sanie, Sawsan; Kim, Jieun; Schmidt-Wilcke, Tobias et al. (2016) Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain. J Pain 17:1-13

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