It is well known that personality and emotions can influence coronary events, and in turn affect mortality. A number of studies have shown a significant correlation between clinical depression and subsequent coronary events. The exact mechanisms underlying this association are however not well characterized. Emerging data has strongly implicated endothelial dysfunction as an important predictor of adverse vascular events. There are a variety of reasons to suspect that endothelial function may be abnormal in depressed patients This include abnormalities in the hypothalamic-pituitary system, sympathoadrenal system and recent data suggesting immune activation. In this study we hope to provide preliminary data demonstrating a link between depression and abnormal vascular reactivity. Further we also hope to provide some mechanistic insights by showing a significant correlation between endothelial dysfunction and cytokine activation in depression.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000042-40
Application #
6408536
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1977-12-01
Project End
2001-02-28
Budget Start
Budget End
Support Year
40
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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