This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many individuals who experience one or more forms of chronic pain in their everyday life. In particular, there are many illnesses that fall under an umbrella called Chronic Multi-symptom Illness (CMI). Such illnesses include, but are not limited to, fibromyalgia (FMS), irritable bowel syndrome (IBS), and temporomandibular disorder (TMD). In this study we will compare and contrast various physiologic findings in individuals who have FMS, IBS, or TMD and will compare and contrast these findings to individuals who have no chronic pain symptoms (controls). Study volunteers will take part in one or more testing session(s) where they will complete a detailed battery of tests and questionnaires involving self-report of pain levels and psychological and cognitive factors. In addition, different types of stimulation (pressure, temperature, electrical, auditory) will be performed to assess individual effects. People who take part in this study will also have a functional MRI scan to look at how pain is processed in the brain. A total of 144 age-, gender-, and race-matched subjects will be studied, 36 FM patients, 36 IBS patients, 36 TMD patients, and 36 controls. Study volunteers will be drawn from a pool of people who completed the Screening Protocol designed by our group. No ethnic groups will be excluded from this protocol.
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