This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this proposal is to determine if nasal saline relieves chronic nasal and sinus symptoms. We will compare forms of nasal saline administration: nasal irrigation and nasal spray. The hypothesis is that nasal saline irrigations will result in greater symptom improvement than nasal saline spray.
The specific aims are 1) To determine if nasal irrigations result in improvement in disease-specific quality of life as measured by change in 20-item Sino-Nasal Outcome Test (SNOT-20) scores. 2) To determine if nasal irrigations, compared with saline spray, result in greater improvement in disease-specific quality of life as measured by change in 20-item Sino-Nasal Outcome Test (SNOT-20) scores. 3) To determine if nasal irrigations or nasal saline spray result in decreased utilization of usual medications for chronic nasal and sinus complaints. The research design is a randomized trial, which will enroll adults with chronic nasal and sinus symptoms. Each subject will be randomly assigned to one of the two treatment arms. Symptom improvement as well as medication usage will be followed over 2 months. The significance of this project is that chronic nasal and sinus disorers affect millions of patients and are responsible for a large portion of outpatient visits and antibiotic usage. Yet, despite unprecedent levels of healthcare utilization for these disorders, studies demonstrate imparied quality of life among these patients. Nasal saline may be an effective treatment, either as add-therapy, or as an alternative to other more expensive medications.
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