This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate the effectiveness of influenza immunization on antibody responsiveness in subjects with normal self reported sleep habits and on those with sleep disorders. The general aim of this project is to determine whether sleep disorders negatively impact immune function. We will determine IgG antibody titers from normal sleepers and from subjects with disturbed sleep, including subjects with insomnia, circadian rhythm disorders (shift workers) and obstructive sleep apnea. Antibody titers will be determined from blood samples taken prior to vaccination and at 10 and 30 days after vaccination. Subjects will have a sleep study performed to confirm inclusion in the appropriate group, and keep logs of sleep and flu symptoms. The deleterious effects of sleep disorders on the immune system, and specifically antibody response to influenza vaccination, have been recently demonstrated in a partial sleep deprivation study, where sleep deprived healthy young adults had an antibody response to immunization of less than half the one of subjects with normal sleep. The impact on immune function of sleep deprivation or sleep disorders in the general population has not been evaluated.
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