This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Post-menopausal women are at very high risk for coronary heart disease and this risk is as high as men, unlike pre-menopausal women. The reasons for this increase in risk for coronary heart disease are yet unclear. One of the mechanisms could be abnormal blood vessel wall function. The purpose of this study is to analyze blood vessel function in women after menopause who have risk factors for coronary heart disease, and to see whether a medication called spironolactone can improve blood vessel function. This study will help us gain a better understanding of blood vessel function in women after menopause, and of the effects of a medication called spironolactone on blood vessel function. The study medication, spironolactone, has been used in heart failure patients with very good survival benefits at minimal cost and minimal side effects. Women who have entered menopause, with at least one risk factor for coronary artery disease (i.e., high blood pressure, diabetes, family history of heart attack or smoking) and who are not taking hormone replacement therapy, will be enrolled in our study. A total of 25 post-menopausal women will participate in this study.'
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