This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The University of Michigan Memory and Aging Project (UM-MAP) within the Michigan Alzheimer's Disease Research Center (MADRC) is being performed to learn more about the types of symptoms that develop in patients with Alzheimer's disease and related disorders during the course of their illness. Participants in the study do not have to change their regular medical care. By observing how symptoms change over time, we hope to learn more about when and why particular symptoms develop and how this affects treatment. The Clinical Core, the Administrative Core, and the Education Core are the primary MADRC cores involved in this project. The Clinical Core serves as the primary contact point for the study volunteer and in collaboration with the Education and Administrative cores, assists with educational materials and activities to promote participation in clinical studies, stimulates the interest of trainees and new investigators, and disseminates research advances widely. The Minority Satellite Diagnostic and Treatment Center at the Ypsilanti Family Practice Center in the Clinical Core serves a large African-American and Hispanic community and ensures a diverse research population from which to draw potential volunteers.Individuals invited to enter UM-MAP include volunteers with normal aging and patients with mild Alzheimer's disease or other difficulties that can affect memory or thinking ability. Once a participant enrolls, he or she must 1) identify a study partner who serves as an informant, 2) name a health care advocate (preferably the same person as the health care advocate), and 3) agree to an annual neurological and neuropsychological screening examination at the University of Michigan General Clinical Research Center. The volunteer is also encouraged to give provisional consent for autopsy as Alzheimer's disease and related illnesses are only confirmed upon autopsy. As part of the study, medical records from the participant's regular Alzheimer's care will also be reviewed to monitor clinical changes that may affect the research diagnosis. The data collected during the annual screening exams, called the Universal Data Set (UDS) will be used in three ways: 1) investigators or the volunteer's clinician may access relevant data to monitor a participant's progression, 2) separate research projects that are approved by the IRB and the Executive Committee may use data for research on dementia, and 3) the data will also be stored in a national database at the National Alzheimer's Coordinating Center(NACC) that pools information from all NIH-funded Alzheimer's Disease Centers under guidelines meeting all HIPPA requirements.'

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
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Application #
Study Section
Special Emphasis Panel (ZRR1-CR-8 (02))
Project Start
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
Zip Code
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