Purpose: To determine the safety and efficacy of a single in vivo gene transfer of the Herpes simplex thymidine kinase gene by infiltrating the surgical resection margin of the tumor with escalating doses of PA317/G1Tk1SvNa.7 vector producer cells followed 14 days later by a two week course of ganciclovir in pediatric patients with progressive or recurrent malignant supratentorial brain tumors.

Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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