There are 3 objectives to study: 1) To establish the MTD of taxotere in patients with varying degrees of liver dysfunction (mild, moderate and severe); 2) To determine the effects of hepatic dysfunction on the plasma pharmacokinetics and pharmacodynamics of taxotere; 3) To study the utility of indocyanine green clear nace and lidocaine matabolism as indicators of taxotere hapatic elimation. Taxotere is an naolog of taxol. It will be administered every three weeks at varying levels depending on hepatice dysfunction.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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