This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot clinical trial in healthy volunteers investigates a new minimally invasive method for clinical measurement of the cardiac output that circumvents limitations of currently available method for invasive and non-invasive monitoring of cardiac output. The new method is based on the transcutaneous detection of indocyanine green fluorescence following an intravenous injection of the dye. The studies aim at comparing different placements of the optical probe on the body surface with respect to intensity and stability fluorescence signal, testing a calibration procedure for the method, and verifying that the new method tracks cardiac output changes induced by passive bed tilt. Successful completion of the proposed trial coupled with ongoing animal studies should produce sufficient preliminary data for an application to the NIH for testing of the technique in critically ill patients by comparison with the reference thermodilution method.
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