This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Graft-versus-host disease (GVHD) represents a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HSCT). In an effort to permit the safe engraftment without GVHD, much effort has focused on testing the GVHD inducing capability in different T cell subsets. Among various hypothesis and methods examined, separation of GVHD inducing T cells based on their differentation status and/or tissue-specific homing receptors is an attractive strategy. In this study, we plan to enumerate naive-memory T cells and gut-specific integrin a4B7+ T cells in allogeneic peripheral stem cell grafts, and correlate with the incidence, severity and site of GVHD post-transplant. We also plan to assess T cell recovery post-transplant with respect to their differentiation status and tissue specific integrin. We plan to examine patients undergoing HSCT from a sibling donor.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000043-49
Application #
7982062
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-12-01
Project End
2009-11-30
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
49
Fiscal Year
2009
Total Cost
$9,277
Indirect Cost
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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