Abstract

Application is made for continued support of a General Clinical Research Center at the University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital. This center has been in continuous operation since 1960, and the program of research activities involves preclinical as well as clinical departments, some in collaboration. Medicine, pediatrics, surgery, psychiatry, neurology, biochemistry, pharmacology, toxicology, and biophysics are represented in over 75 protocols; 71 investigators currently use our resources. The disciplines represented include Neuroendocrinology, Metabolism, Nutrition, Pulmononology, Neonatology, Infectious Disease, Cardiology, Nephrology, and the areas of Neuromuscular and Neurodegenerative Diseases. Areas of research focus include: Surfactant and Steroid Therapy in Respiratory Distress Syndrome and Bronchopulmonary Dysplasia of the newborn; Sulfate and Nitrate Aerosol effects on pulmonary gas exchange and cellular defense mechanisms; Therapeutic drug trials in AIDS; Energy homeostasis and protein synthesis in the obese; Neuroendocrine control of pituitary function in aging and in brain trauma; Muscle protein synthesis and degradation in wasting neuromuscular diseases; Anti-oxidative therapeutic trials in Parkinson's Disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000044-33
Application #
3089349
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1974-10-01
Project End
1994-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
33
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Di Fiore, Juliann M; Martin, Richard J; Li, Hong et al. (2017) Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort. J Pediatr 186:49-56.e1
Ternullo, Sharon R; Abdolahi, Amir; Williams, Geoffrey C (2017) Study of monotherapy versus combination therapy for tobacco dependence among heavily addicted smokers. J Am Pharm Assoc (2003) 57:77-81.e1
Younge, Noelle; Goldstein, Ricki F; Bann, Carla M et al. (2017) Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 376:617-628
Williams, Geoffrey C; Niemiec, Christopher P; Patrick, Heather et al. (2016) Outcomes of the Smoker's Health Project: a pragmatic comparative effectiveness trial of tobacco-dependence interventions based on self-determination theory. Health Educ Res 31:749-759
Archer, Stephanie Wilson; Carlo, Waldemar A; Truog, William E et al. (2016) Improving publication rates in a collaborative clinical trials research network. Semin Perinatol 40:410-417
Ettensohn, David B; Frampton, Mark W; Nichols, Joan E et al. (2016) Human Alveolar Macrophages May Not Be Susceptible to Direct Infection by a Human Influenza Virus. J Infect Dis 214:1658-1665
Phelps, Dale L; Ward, Robert M; Williams, Rick L et al. (2016) Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants. Pediatr Res 80:209-17
Foglia, Elizabeth E; Nolen, Tracy L; DeMauro, Sara B et al. (2015) Short-term Outcomes of Infants Enrolled in Randomized Clinical Trials vs Those Eligible but Not Enrolled. JAMA 313:2377-9
O'Connor, Thomas G; Wang, Hongyue; Moynihan, Jan A et al. (2015) Observed parent-child relationship quality predicts antibody response to vaccination in children. Brain Behav Immun 48:265-73

Showing the most recent 10 out of 509 publications