This is an ancillary study of the Phase II multicenter, randomized, placebo-controlled trial of hydroxyurea therapy for sickle cell disease. Both UNC and Duke are taking part in this trial. During Phase I of the study, 26 of the 32 patients treated gained weight. This study will make use of the opportunity provided by a Phase II study to investigate the etiology, tissue composition, and any change in muscle function that accompanies weight gain associated with HU therapy.

Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost
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