The purpose of this study is to determine the safety of hydroxyurea in children with sickle cell anemia between the ages 5 and 15 years of age, by giving an escalating dose regimen of the drug and monitoring hematologic, renal and hepatic indicies, and monitoring the subjects' growth. The study will also provide information on the effects of hydroxyurea on the level of fetal hemoglobin, in the percentage of F-cells, the hemoglobin and MCV in children with sickle cell anemia.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000046-39S2
Application #
6217979
Study Section
Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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