Abstract

This study will test the theory that IDU's may have higher expression of iNOS than controls, which may explain the observed association of a Nitric Oxide resistant strain with IDU's. Initially 10 HIV-negative IDU volunteers will be recruited from outpatient clinics at New York and Hospitals. They will be compared to 10 age, sex and smoking history- matched non-IDU HIV negative controls. Blood samples will be tested for iNOS expression and evidence of Nitric Oxide production.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000047-38
Application #
6275249
Study Section
Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

de Simone, Giovanni; Wang, Wenyu; Best, Lyle G et al. (2017) Target organ damage and incident type 2 diabetes mellitus: the Strong Heart Study. Cardiovasc Diabetol 16:64
Gerber, Linda M; Sievert, Lynnette L; Schwartz, Joseph E (2017) Hot flashes and midlife symptoms in relation to levels of salivary cortisol. Maturitas 96:26-32
De Marco, Marina; Gerdts, Eva; Mancusi, Costantino et al. (2017) Influence of Left Ventricular Stroke Volume on Incident Heart Failure in a Population With Preserved Ejection Fraction (from the Strong Heart Study). Am J Cardiol 119:1047-1052
Schachterle, William; Badwe, Chaitanya R; Palikuqi, Brisa et al. (2017) Sox17 drives functional engraftment of endothelium converted from non-vascular cells. Nat Commun 8:13963
Haring, Bernhard; Wang, Wenyu; Fretts, Amanda et al. (2017) Red meat consumption and cardiovascular target organ damage (from the Strong Heart Study). J Hypertens 35:1794-1800
Beheshtian, Azadeh; Shitole, Sanyog G; Segal, Alan Z et al. (2016) Lipoprotein (a) level, apolipoprotein (a) size, and risk of unexplained ischemic stroke in young and middle-aged adults. Atherosclerosis 253:47-53
Leung, Vivien; Chiu, Ya-Lin; Kotler, Donald P et al. (2016) Effect of Recombinant Human Growth Hormone and Rosiglitazone for HIV-Associated Abdominal Fat Accumulation on Adiponectin and other Markers of Inflammation. HIV Clin Trials 17:55-62
de Simone, Giovanni; Roman, Mary J; De Marco, Marina et al. (2015) Hemodynamic Correlates of Abnormal Aortic Root Dimension in an Adult Population: The Strong Heart Study. J Am Heart Assoc 4:e002309
Bhatia, Rajeev; Lesser, Daniel J; Oliveira, Flavia G S A et al. (2015) Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children. J Clin Sleep Med 11:1039-45
Ocean, Allyson J; Christos, Paul; Sparano, Joseph A et al. (2014) Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach. Invest New Drugs 32:542-8

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