This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.By analyzing the rapid changes in HCV RNA levels, the molecular genetic evolution that immediately follows initiation of antiviral therapy with pegylated interferon and ribavirin, and by an evaluation of the differential host gene expression between responders and non-responders, we may gain important insight regarding chronic hepatitis C virus infection treatment failure. The study groups will comprise Caucasians with HCV genotype 1 infection, African Americans with genotype 1 infection and Caucacians with genotype 2 or 3. These are groups with disparate therapy outcomes that should best illustrate differences in virus host response.
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