This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Hypothesis:Due to the presumed avoidance of the first-pass effect and metabolism by gut cytochrome enzymes in HIV-1 infected women of reproductive age, it is hypothesized that there will be no difference in EE area under the concentration-time curve (AUC) at transdermal contraception week 3 (study weeks M+3 to M+4) between women on stable LPV/r and those not on PIs or NNRTIs or on any ARV therapy.Primary Objectivs:To evaluate the effect of LPV/r on the PK of EE in HIV-1-infected women of reproductive age by comparing the EE AUC during ORTHO EVRA transdermal contraceptive patch week 3 (study weeks M+3 to M+4) in women on LPV/r with the EE AUC measured in women who are not receiving PIs, NNRTIs, or any ARV therapy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000047-47
Application #
7604220
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2007-09-16
Budget Start
2007-04-01
Budget End
2007-09-16
Support Year
47
Fiscal Year
2007
Total Cost
$5,265
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
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