The goals of this project are 1) to determine the safety of rhu IL-1R administered intra-articularly in rheumatoid arthritis patients with active synovitis; 2) to evaluate the effectiveness of rhu IL-1R in modifying local joint inflammation; and 3) to determine the systemic pharmacokinetic parameters of rhu IL-1R when administered intra-articularly into a joint with active inflammation.
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| Nodzenski, Michael; Muehlbauer, Michael J; Bain, James R et al. (2014) Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data. Bioinformatics 30:3287-8 |
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