High Dose Phenylbutyrate Therapy in Patients with Chronic Liver Disease

Blei, Andres T.

Abstract

Phenylbutyrate, a drug used in children with congenital deficiencies in urea cycle enzymes, is biotransformed to phenylacetate, an alternative pathway for nitrogen excretion. This drug may be useful as an agent to treat hyperammonemia in liver disease. Six patients are receiving the drug for a period of 8 days to assess the integrity of the metabolic pathway.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 5M01RR000048-34
• Application #: 3740037
• Support Year: 34
• Fiscal Year: 1995

Institution

• Name: Northwestern University at Chicago
• DUNS #: 005436803
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60611

Publications

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Slama, Laurence; Jacobson, Lisa P; Li, Xiuhong et al. (2016) Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men. J Acquir Immune Defic Syndr 71:57-64

Ye, Wen; Rosenthal, Philip; Magee, John C et al. (2015) Factors Determining ?-Bilirubin Levels in Infants With Biliary Atresia. J Pediatr Gastroenterol Nutr 60:659-63

Arroyo-Ávila, Mariangelí; Santiago-Casas, Yesenia; McGwin Jr, Gerald et al. (2015) Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34:1217-23

Lin, Pin; Rhew, Elisa; Ness, Roberta B et al. (2014) Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus. Lupus Sci Med 1:e000024

Torchen, Laura C; Fogel, Naomi R; Brickman, Wendy J et al. (2014) Persistent apparent pancreatic ?-cell defects in premenarchal PCOS relatives. J Clin Endocrinol Metab 99:3855-62