We have recently completed a study at the GCRC where we found a striking abnormality of the diurnal rhythm of plasma melatonin in non-alcoholic cirrhotic subjects. This consisted of a delayed onset of melatonin secretion as well as a delay in the peak time of nocturnal melatonin levels--findings that are suggestive of a phase shift of the """"""""biological clock."""""""" Correction of the parameters suggestive of a disruption of the circadian clock would confirm the hypothesized relation between hepatic encephalopathy and circadian function.

Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
1996
Total Cost
Indirect Cost
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