This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the past few years great progress has been made in uncovering the molecular basis for the generation of circadian rhythms in mammals. These molecular studies in rodents and flies have stimulated a search for genetic differences that could underlie altered circadian rhythms and/or sleep disorders in humans. Two of the most common sleep disorders in humans that are thought to be due to alterations in circadian timing are classified as the Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS). DSPS is characterized by a persistent inability to initiate sleep before 2 to 6 AM and difficulty waking up until 10 AM to 1 PM, whereas, ASPS is characterized by habitual and involuntary sleep and wake times that are at least several hours earlier than societal means. The most common complaints are sleepiness in the late afternoon or evening, and early morning awakening of 2-5 AM. Based on studies of extended families, there are now two recent reports indicating that both ASPS and DSPS can have a genetic basis, and may be due to allelic differences in at least two of the newly discovered circadian clock genes. In addition, a recent study of sporadic DSPS indicates that allelic differences in a second clock gene may underlie this condition. While studies on the genetic basis of DSPS and ASPS represent a new and exciting avenue to elucidate how the sleep-wake and circadian clock systems are integrated with each other, and how alterations in specific circadian clock genes can lead to alterations in the timing of sleep and wake, our understanding of the physiological mechanisms responsible for these circadian sleep disorders is actually quite limited. One of the objectives of the parent NIH funded grant is to test various hypotheses that could explain how an alteration in the circadian clock system could lead to changes in the phase of the sleep-wake cycle relative to the light-dark cycle. The objective of this project is to test the hypothesis that the altered circadian phase in ASPS or DSPS is due to an alteration in the way that the circadian clock responds to light.
| Sherenian, Michael G; Singh, Anne M; Arguelles, Lester et al. (2018) Association of food allergy and decreased lung function in children and young adults with asthma. Ann Allergy Asthma Immunol 121:588-593.e1 |
| Baron, Kelly Glazer; Reid, Kathryn J; Malkani, Roneil G et al. (2017) Sleep Variability Among Older Adults With Insomnia: Associations With Sleep Quality and Cardiometabolic Disease Risk. Behav Sleep Med 15:144-157 |
| Makhija, Melanie M; Robison, Rachel G; Caruso, Deanna et al. (2016) Patterns of allergen sensitization and self-reported allergic disease in parents of food allergic children. Ann Allergy Asthma Immunol 117:382-386.e1 |
| Gupta, Ruchi S; Walkner, Madeline M; Greenhawt, Matthew et al. (2016) Food Allergy Sensitization and Presentation in Siblings of Food Allergic Children. J Allergy Clin Immunol Pract 4:956-62 |
| Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2016) Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: A comparative analysis of the primate basal ganglia. J Comp Neurol 524:2117-29 |
| Slama, Laurence; Jacobson, Lisa P; Li, Xiuhong et al. (2016) Longitudinal Changes Over 10 Years in Free Testosterone Among HIV-Infected and HIV-Uninfected Men. J Acquir Immune Defic Syndr 71:57-64 |
| Ye, Wen; Rosenthal, Philip; Magee, John C et al. (2015) Factors Determining ?-Bilirubin Levels in Infants With Biliary Atresia. J Pediatr Gastroenterol Nutr 60:659-63 |
| Arroyo-Ávila, Mariangelí; Santiago-Casas, Yesenia; McGwin Jr, Gerald et al. (2015) Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34:1217-23 |
| Nodzenski, Michael; Muehlbauer, Michael J; Bain, James R et al. (2014) Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data. Bioinformatics 30:3287-8 |
| Scholtens, Denise M; Muehlbauer, Michael J; Daya, Natalie R et al. (2014) Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care 37:158-66 |
Showing the most recent 10 out of 189 publications
