This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primary objective of this study is to elucidate the etiology of racial differences in extrarenal potassium metabolism. In a recent study, we demonstrated that African Americans tend to have higher serum K+ levels after an IV infusion than do Caucasians. It has been postulated that this is due to sluggish Na+K+ ATPase pump activity in African Americans This is thought to be mediated by non-neuronal dopamine from abundant melatonin precursors. Our previous study with carbidopa - a non-specific dopamine synthesis inhibitor, failed to show this, possibly because of its non-specific blockage. For this reason we are now to embark on a study using a dopamine receptor antagonist, metochlopramide, and compare this to carbidopa and placebo to see if this racial difference is obliterated.
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| Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan R et al. (2014) Risk factors in the progression of subclinical atherosclerosis in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 66:1177-85 |
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