This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Studies have shown that HIV can survive in cells for long periods of time even while a person is on HIV therapy. The HIV virus can survive in these cells for a very long time in a 'resting' or 'latent' state. The virus in these cells is not active but could become active in the future. The main purpose of this research study is to count the number of cells with HIV that are resting, or latent, in the blood of people taking a new combination of HIV drugs. The latent reservoir test has not been proven to be of clinical benefit. The combination of HIV drugs includes an investigational HIV drug called T-20 (enfuvirtide, or Fuzeon), which is not approved by the U. S. Food and Drug Administration (FDA). This study will look at the safety of T-20 when it is given with four FDA-approved HIV drugs. These other drugs are tenofovir (TDF, or Viread), lamivudine (3TC, or Epivir), saquinavir (SQV, or Invirase), and ritonavir (RTV, or Norvir). The dosage (dose and schedule) of ritonavir and saquinavir in this study were chosen based on experience in the treatment of people with HIV, but are different than the FDA-approved dosages.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000051-47
Application #
7719441
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-04-01
Project End
2008-05-31
Budget Start
2008-04-01
Budget End
2008-05-31
Support Year
47
Fiscal Year
2008
Total Cost
$975
Indirect Cost
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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