This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Our goal is to help older adults with cancer live healthier, more productive lives by protecting their muscles from the effects of cancer and/or cancer treatment. Androgen-deprivation therapy (ADT), a common treatment for prostate cancer, dramatically reduces the levels of the sex hormone testosterone in the blood to protect the prostate. ADT is beneficial in delaying the progression or recurrence of prostate cancer, but it also causes the loss of muscle. These changes in muscle are troubling because they cause weakness and can impair quality of life. Furthermore, the age at which men are typically diagnosed with prostate cancer (50 - 80 y) is in itself associated with a loss of muscle mass and strength. Thus, ADT may cause premature frailty in older men. We are proposing that resistance exercise training (weight lifting) can offset changes in muscle biology due to ADT and cause an increase in muscle mass (hypertrophy). In this preliminary study, we will determine the effectiveness of resistance exercise training to offset changes in muscle biology in men who have been undergoing ADT. We will measure changes in specific genes important to muscle breakdown and growth in response to ADT and resistance exercise training.
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