The most significant observation in patients with Rett syndrome has been the recognition of reduced Dopamine D2 receptors in the caudate by PET studies confirming the pathologic observation of reduced melanin containing cells in the substantia nigra, reduced dopamine in brain tissues and reduced receptors noted in one reported autopsy case. The cholinergic cells and choline acetyl transferase are also reduced in the brain.

Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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