These studies represent a small independent add-on to two NIH funded investigations into brain structure in psychosis. We wished to explore whether patients with hallucinations and delusions in diverse neuropsychiatric disorders, including schizophrenia, manic depressive illness, and Alzheimer's disease, show abnormalities of common anatomical substrates compared to age-matched controls. In particular, we hypothesized that disease involvement of temporal limbic and neocortical regions would predispose to psychosis. We found that a disproportionate involvement of mesiel temporal regions and posterior superior temporal gyrus, especially on the left side, appeared to be a common mechanism across psychotic states.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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