This study addresses several questions:1)what will be the maximal tolerated dose of AAV-CFTR in the lungs of pts., with mild lung disease2)will AAV-CFTR vector expression be detectable in the lungs of CF pts. after receiving a dose that results in no toxic effects3)what will be the efficiency & duration of expression of AAV-CFTR after administratin to the respiratory epithelium in the nose. The answers to these questions will provide vital information relevant to any future AAV-based gene therapy.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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