The hypothesis of this Phase II trial is that two treatment combinations, indicated below, will be effective in reducing HIV viral load and will be well tolerated. Children will be randomized to one of the 2 following 2 treatment arms: Arm 1: Saquinavir soft gel capsule (50 mg/kg po TID; maximum, 1200 mg po TID), plus two nucleoside reverse transcriptase inhibitors (NRTIs) of choice Arm 2: Saquinavir soft gel capsule (50 mg/kg po BID; maximum 1200 mg po BID) plus nelfinavir (55 mg/kg po BID; maximum 1500 mg po BID) plus one or two NRTIs of choice The primary specific aim of this study is to assess the tolerance and safety of orally administered saquinavir soft gel capsule (SQV-SGC) given in combination with two NRTIs or orally administered SQV-SGC and nelfinavir and one or two NRTIs.
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| Aboud, Katherine S; Barquero, Laura A; Cutting, Laurie E (2018) Prefrontal mediation of the reading network predicts intervention response in dyslexia. Cortex 101:96-106 |
| Kattan, Meyer; Bacharier, Leonard B; O'Connor, George T et al. (2018) Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. J Allergy Clin Immunol Pract 6:1596-1603.e6 |
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| Salemi, Parissa; Skalamera Olson, Julie M; Dickson, Lauren E et al. (2018) Ossifications in Albright Hereditary Osteodystrophy: Role of Genotype, Inheritance, Sex, Age, Hormonal Status, and BMI. J Clin Endocrinol Metab 103:158-168 |
| Robert Braši?, James; Mari, Zoltan; Lerner, Alicja et al. (2018) Remission of Gilles de la Tourette Syndrome after Heat-Induced Dehydration. Int J Phys Med Rehabil 6: |
| Altman, Matthew C; Whalen, Elizabeth; Togias, Alkis et al. (2018) Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol 142:1856-1866 |
| AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786 |
| Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671 |
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