Rasmussen syndrome is a constellation of symptons of unexplained onset, consisting of intractable focal motor seizures. The immune mediated inflammatory process of Rasmussen's syndrome can be stopped by immunoablation with high dose cyclosphosphamide.
Our aim i s to treat Rasmussen's syndrom with a high dose cyclophosphamide resulting in peripheral immunoablation. This will hopefully lead to an arrest of the central nervous system inflammatory process that is the hallmark of this disease. If the remission is durable, children could then be spared the morbidity associated with a hemispherectomy. This protocol would provide pilot data for submission of a larger grant to investigate this therapy more fully.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000052-41
Application #
6590630
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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