This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol allows us to capture longitudinal information from HIV seropositive subjects providing an active surveillance system for the identification of HIV-associated cognitive impairment and dementia among patients referred to the HIV Neurology Consultation services, from the Multicenter AIDS Cohort Study (MACS) and patients from the Johns Hopkins Moore Clinic (for patients with HIV infection). In publications this year, we found that combination antiretroviral therapy including protease inhibitors improves cognitive impairment (Sacktor, 2000). Highly active antiretroviral therapy has also decreased the incidence of HIV-associated neurological diseases (Sacktor, 2000). In another study, we evaluated associations between measures of cognitive performance and commonly used measures of daily functioning (Schifitto, 2000). We also evaluated cognitive, neurological/medical, and functional risk factors for incident HIV dementia (Stern, 2000)
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